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KMID : 1149220020100010143
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Korean Journal of Oriental Medical Prescription
2002 Volume.10 No. 1 p.143 ~ p.155
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Anti-leukemic effects of JIPAESAN and its components on leukemic cells HL-60
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Hwang Gi-Myeong
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Abstract
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In the hope of identifying anti-leukemic agents from traditional herbal medicines. this study was designed to investigate the anti-leukemic effects of the herbal medicine Jipaesan, which is composed of Angelica Dahurica and Fritillariae Verticillata. in acute promyeloid leukemia HL-60 cells. Jipaesan showed anti-proliferative effect through the induction of differentiation and apoptosis in HL -60 cells. Verticinone as a major differentiating agent and imperatorin as major apoptosis-inducing agent were isolated from the water extracts of F. Verticillata and A. Dahurica, respectively. Combined treatment of HL-60 cells with two major compounds showed synergy in the induction of differentiation. Since the induction of differentiation and/or apoptosis has therapeutic values in curing acute leukemic diseases. Jipaesan could be useful as an anti-leukemic agent.
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KEYWORD
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Jipaesan, Angelica Dahurica, Fritillariae Verticillata, imperatorin, Verticinone, leukemia
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